What is the effectiveness of metformin in treating type 2 diabetes? How much can blood
sugar levels be lowered with this medication and how long do the effects last after
stopping it?

Metformin is very effective.

Detailed studies state metformin starts lowering IR insulin resistance in endocrine cells
after a week since you took it. It will completely stop working 30 days after you last took
the medication.

It isn't the high blood sugar that kills T2Ds. It is CVD! Metformin cuts CVD risk in half!
That is why Drs prescribe it.

It fixes what is broken in type 2 diabetes. T2D is caused by too much damage to your
lambda cells. Metformin stimulates the damaged lambda cells to make GLP-1 again and
your body isn't actively T2D as long as the metformin is in effect.

It doesn't repair the damage. The damage is permanent and lambda cells that are
damaged can't reproduce like undamaged cells. That means that metformin gradually
stops working.

We used to have to start taking insulin that does not slow CVD progression like
metformin. Now we can take GLP-1 agonists which acts like GLP-1 in your body but is
not chemically identical.

It is close enough that it activates GLP-1 receptors in endocrine cell walls.

When you stop taking metformin you become an active T2D again. That means your arteries harden 4 times faster than normal people.

Both keto diets and IF intermittent fasting don't fix your lambda cells instead they
prevent the liver from getting enough glucose to raise your BG blood glucose.

Your body maintains your BG by dumping glucose stored in your liver when your BGs
become low. If you don't have enough stored glucose in your liver, it doesn't

Your endocrine system is still dysfunctional and you are still 5 times more likely to have
a heart attack. Metformin cuts your heart attack risk in half.

This is a very big deal! You ONLY have a 2.5 times higher risk of heart attack. What it
also means is you reduce the speed in half how fast your arteries harden.

The endocrine cells in your artery walls can't make enough hormones to protect artery
walls from damage.

As long as you take metformin, the destruction in your arteries slows. That is why Drs
prescribe metformin and not keto diets or intermittent fasting.

You will live longer that way. That is why metformin is a far better treatment for T2D
than changing your diet. Diets CAN help but I have never seen a study where diet slows
death by more than 10%.

Diet doesn't slow your death much at all. Too bad your average moron thinks diet is the
most important way to fight T2D. The joke is that taking an ARB BP medication before
bed cuts your heart attack risk by more than 50% and lowers your T2D risk by 70% if
you are a pre-diabetic. I take the 70% over the 10% improvement. I take both an ARB
and beta blocker before bed.

You can read about how and why taking BP medication before bed is so important in my
answers you can read in my profile.

About 70% of my answers are about health and medicine. The rest are on history,
politics and scientific theories.

Full story: https://www.quora.com/What-is-the-effectiveness-of-metformin-in-treating-type-2-
diabetes-How-much-can-blood-sugar-levels-be-lowered-with-this-medication-and-how-
long-do-the-effects-last-after-stopping-it

Mike Dippel

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* Origin: The Hobby Line! BBS (999:1/1)